LOW DOSE
NALTREXONE
(LDN)
One of the most underutilized tools in functional medicine. LDN works by briefly blocking opioid receptors, triggering your body to produce a surge of natural endorphins — your own built-in anti-inflammatory, immune-modulating system.
Dr. Rucker has been prescribing LDN to his patients for years. Now he's making it accessible to everyone — with a free first month (just $20 for shipping and handling).
What Is Low Dose Naltrexone?
Naltrexone is FDA-approved at 50mg for opioid and alcohol use disorders. At 1.5–4.5mg — a fraction of the standard dose — it behaves completely differently. Instead of blocking opioid receptors long-term, it creates a brief blockade that triggers a powerful rebound: your body floods itself with endorphins and upregulates opioid receptors, producing measurable anti-inflammatory and immune-modulating effects.
Brief Receptor Block
LDN temporarily blocks opioid receptors for 4–6 hours, typically taken at bedtime to align with the body's natural endorphin production cycle.
Endorphin Surge
The brief block triggers a compensatory surge in endogenous endorphins (beta-endorphin, met-enkephalin), your body's own natural pain-relieving, mood-lifting compounds.
Immune Modulation
LDN directly acts on microglial cells in the brain and spinal cord, reducing neuroinflammation and modulating cytokine activity — the root driver of many chronic conditions.
What LDN Can Help With
Research and clinical experience support LDN across a wide range of conditions driven by inflammation, immune dysregulation, and chronic pain.
Why I Prescribe LDN
"Most of my patients come to me already on TRT or peptides, and they're doing well — but there's a subset who still feel inflamed, foggy, or fatigued despite optimized hormones. That's where LDN has been a game-changer in my practice."
"LDN addresses something that testosterone and peptides don't directly target: the underlying immune dysregulation and neuroinflammation that keeps people stuck. When you reduce that chronic low-grade fire, everything else works better — your hormones, your sleep, your recovery, your mood."
"I start most patients at 1.5mg at bedtime and titrate up to 4.5mg over 4–6 weeks. Side effects are minimal — some vivid dreams in the first week or two, which typically resolve. The cost is low, the safety profile is excellent, and the upside for the right patient is significant."
"I'm offering a free first month because I want patients to experience what LDN can do without any financial barrier. If it works for you — and for most people it does — you'll want to stay on it."
Learn More About LDN
Watch leading physicians and researchers explain the science behind Low Dose Naltrexone.
LDN Explained: A Doctor's Guide to Pain, Inflammation & Autoimmunity
LDN, Inflammation & Chronic Pain — Dr. Jeffrey Morrison
How to Treat Chronic Pain Using Low Dose Naltrexone
Low-Dose Naltrexone: Hype, Hope, or Homerun?
Typical Dosing Protocol
Taken at bedtime. Allows body to adjust; some patients notice vivid dreams — this is normal and temporary.
Titrate up if tolerating well. Most patients notice improved energy and reduced inflammation by week 3.
Maintenance dose for most patients. Some do well at 3mg — Dr. Rucker will guide your titration.
* LDN is a compounded prescription medication. Dr. Rucker will review your intake form and issue a prescription before your order ships.
Common Questions
Is LDN FDA-approved?
Naltrexone is FDA-approved at 50mg for opioid and alcohol use disorders. LDN (1.5–4.5mg) is used off-label — a common and legal practice in medicine. It is compounded by a licensed pharmacy and prescribed by Dr. Rucker.
Can I take LDN with TRT or peptides?
Yes — LDN pairs very well with TRT and peptide protocols. It addresses systemic inflammation that can blunt hormone response, making your existing protocol more effective. Just avoid taking LDN within 4 hours of any opioid medication.
What are the side effects?
LDN has an excellent safety profile. The most common side effect is vivid or unusual dreams in the first 1–2 weeks, which typically resolve on their own. Nausea is occasionally reported and usually resolves with food.
How long before I notice results?
Most patients notice improved energy and reduced brain fog within 2–4 weeks. Anti-inflammatory and immune effects build over 6–12 weeks of consistent use.
What happens after the free month?
There is no auto-enrollment. After your free month, Dr. Rucker's team will follow up to discuss whether to continue. Ongoing LDN is very affordable — typically $30–$60/month through our compounding pharmacy.
Do I need to be an existing Reverse Medical patient?
No — this offer is open to anyone. Dr. Rucker will review your intake form and issue a prescription. If you're already a patient, your existing chart will be used.
Claim Your Free Month of LDN
Pay only $20 for shipping & handling. Dr. Rucker reviews your intake, issues your prescription, and your LDN ships directly to your door. No hidden fees. No auto-enrollment.
Get Started — $20 Shipping OnlyMedical disclaimer: LDN is a prescription medication. This offer is subject to Dr. Rucker's clinical review. Not available in all states.